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White and the Vancouver Whitecaps visit Minnesota United

Vancouver Whitecaps FC (8-7-4, eighth in the Western Conference) vs. Minnesota United FC (8-7-5, seventh in the Western Conference) Saint Paul, Minnesota; Wednesday, 8:30 p.m.

Cincinnati faces D.C. United after shutout victory

FC Cincinnati (13-4-3, second in the Eastern Conference) vs. DC United (4-9-8, 11th in the Eastern Conference) Washington; Wednesday, 7:30 p.m. EDT BETMGM SPORTSBOOK : LINE FC Cincinnati +152, DC United +157, Draw +243; over/under is 2.

Columbus Crew host Nashville in non-conference play

Nashville SC (6-6-8, 11th in the Western Conference) vs. Columbus Crew (9-3-6, fourth in the Eastern Conference) Columbus, Ohio; Wednesday, 6:30 p.m. EDT BETMGM SPORTSBOOK : LINE Columbus -243, Nashville SC +600, Draw +363; over/under is 2.

New England Revolution host Atlanta United in Eastern Conference action

Atlanta United FC (6-8-6, seventh in the Eastern Conference) vs. New England Revolution (6-11-1, 13th in the Eastern Conference) Foxborough, Massachusetts; Wednesday, 7:45 p.m.

Houston Dynamo face Real Salt Lake after shutout victory

Houston Dynamo (8-6-6, fifth in the Western Conference) vs. Real Salt Lake (10-3-7, third in the Western Conference) Sandy, Utah; Wednesday, 9:30 p.m. EDT BETMGM SPORTSBOOK : LINE Real Salt Lake -131, Houston +327, Draw +272; over/under is 2.

New York City FC hosts CF Montreal in Eastern Conference play

CF Montreal (5-8-7, ninth in the Eastern Conference) vs. New York City FC (10-8-2, fifth in the Eastern Conference) , ; Wednesday, 7:30 p.m. EDT BETMGM SPORTSBOOK : LINE NYCFC -260, Montreal +583, Draw +401; over/under is 3.

Toronto hosts Orlando City on 3-game home losing streak

Orlando City SC (5-9-6, 10th in the Eastern Conference) vs. Toronto FC (7-11-3, seventh in the Eastern Conference) Toronto; Wednesday, 7:30 p.m. EDT BETMGM SPORTSBOOK : LINE Toronto FC +131, Orlando City SC +187, Draw +241; over/under is 2.

Inter Miami aims to extend win streak in matchup with Charlotte FC

Inter Miami CF (13-3-5, first in the Eastern Conference) vs. Charlotte FC (9-7-5, fifth in the Eastern Conference) Charlotte, North Carolina; Wednesday, 7:30 p.m.

San Jose Earthquakes look to break losing streak in matchup with Saint Louis City SC

San Jose Earthquakes (3-15-2, 15th in the Western Conference) vs. Saint Louis City SC (3-7-10, 13th in the Western Conference) Old North Saint Louis, St. Louis; Wednesday, 8:30 p.m.

Philadelphia Union try to break losing streak in matchup with the Chicago Fire

Philadelphia Union (4-8-8, 11th in the Eastern Conference) vs. Chicago Fire (4-10-6, 14th in the Eastern Conference) Chicago; Wednesday, 8:30 p.m. EDT BETMGM SPORTSBOOK : LINE Chicago +103, Philadelphia +238, Draw +246; over/under is 2.